Blackburn Rovers had a man sent-off early on, but still went on to take three points.
Paraguay striker Roque Santa Cruz scored with two headers either side of an equaliser for the Latics' Marlon King and a goal from Jason Roberts on the stroke of half-time.
Rovers lost Christopher Samba to a 17th-minute red card for bringing down Emile Heskey in the incident which led to King's penalty but that only spurred them on.
